Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo
Transgene Detail

Summary

• Symbol: Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo
• Name: transgene insertion Y74, David R Borchelt
• MGI ID: MGI:5615836
• Synonyms: TUL-Y74
• Transgene: Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo Location: unknown
• Alliance: Tg(tetO/Prnp-MAPT*P301L,-luc)Y74Dbo page

Transgene origin

• Strain of Origin: FVB/NJ

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The transgenic construct includes a Tet-responsive element (TRE) and exons 1-2 (non-coding) from the mouse prion protein upstream of a Tau-Ubiquitin-Luciferase (TUL) cDNA sequence, followed by mouse prion protein exon 3 (non-coding) and polyadenylation signal. The TUL cDNA sequence encodes a mutant human tau-P301L with C-terminal ubiquitin, followed by a luciferase gene. (J:101977, J:234694)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:234694 Fromholt S, et al., Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimers Res Ther. 2016;8:36
• All: 2 reference(s)