Mirc36^tm1.1Jcav
Targeted Allele Detail

Summary

• Symbol: Mirc36^tm1.1Jcav
• Name: microRNA cluster 36, including Mir379 through Mir3072; targeted mutation 1.1, Jerome Cavaille
• MGI ID: MGI:5614047
• Gene: Mirc36 Location: Chr12:109675494-109714394 bp Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:216177
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Mirc36^tm1.1Jcav involves 44 genes/genome features (Gm24321, Gm25252, Gm25750 ...) View all
• Mutation details: Two targeting vectors harboring neomycin- and hygromycin-resistance expression cassettes were introduced upstream and downstream, respectively, of the micro-RNA cluster. This was achieved through two independent homologous recombination events. The whole cluster was then deleted by cre mediated excision. (J:216177)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mirc36 Mutation: 1 strain or line available

References

• Original: J:216177 Labialle S, et al., The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation. EMBO J. 2014 Oct 1;33(19):2216-30
• All: 3 reference(s)