Rp2^tm1.1Asw
Targeted Allele Detail

Summary

• Symbol: Rp2^tm1.1Asw
• Name: retinitis pigmentosa 2 homolog; targeted mutation 1.1, Anand Swaroop
• MGI ID: MGI:5613810
• Synonyms: Rp2^flox
• Gene: Rp2 Location: ChrX:20230720-20271892 bp, + strand Genetic Position: ChrX, 15.83 cM, cytoband A2
• Alliance: Rp2^tm1.1Asw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214194
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neomycin resistance cassette was inserted downstream of exon 2. Flp-mediated recombination removed the selection cassette and left exon 2 floxed. (J:214194)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rp2 Mutation: 6 strains or lines available

References

• Original: J:214194 Li L, et al., Ablation of the X-linked retinitis pigmentosa 2 (Rp2) gene in mice results in opsin mislocalization and photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2013 Jul;54(7):4503-11
• All: 3 reference(s)