Tap2^m2Btlr
Chemically induced Allele Detail

Summary

• Symbol: Tap2^m2Btlr
• Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP); mutation 2, Bruce Beutler
• MGI ID: MGI:5613166
• Synonyms: date
• Gene: Tap2 Location: Chr17:34423453-34435295 bp, + strand Genetic Position: Chr17, 17.98 cM
• Alliance: Tap2^m2Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU) (Null/knockout)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis induced a T to A transversion at base pair 34,212,354 (v38) on chromosome 17, or base pair 8,270 in the GenBank genomic region NC_000083. The mutation corresponds to residue 1,418 in the mRNA sequence NM_011530 within exon 7 of 12 total exons. The mutation results in a valine (V) to aspartic acid (D) substitution at position 422 (V422D), and is strongly predicted by Polyphen-2 to cause loss of function (score = 0.989). (J:217145)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tap2 Mutation: 28 strains or lines available

References

• Original: J:217145 Choi JH, et al., Mutagenetix entry for date. MGI Direct Data Submission. 2015
• All: 1 reference(s)