Tnfrsf19^{tm1.1(cre/ERT2)Cle}
Targeted Allele Detail

Summary

• Symbol: Tnfrsf19^{tm1.1(cre/ERT2)Cle}
• Name: tumor necrosis factor receptor superfamily, member 19; targeted mutation 1.1, Hans Clevers
• MGI ID: MGI:5613002
• Synonyms: Troy-eGFP-ires-CreERT2, Troy-ki^ki
• Gene: Tnfrsf19 Location: Chr14:61201324-61283939 bp, - strand Genetic Position: Chr14, 32.06 cM
• Alliance: Tnfrsf19^{tm1.1(cre/ERT2)Cle} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:214484
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase, Reporter)
• Inducer: tamoxifen
• Mutations: Insertion, Intragenic deletion
• Tnfrsf19^{tm1.1(cre/ERT2)Cle} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tnfrsf19 (MGI:1352474)

• Mutation details: An EGFP, IRES, cre/ERT2 fusion, and floxed neomycin resistance cassette replaced the coding sequence in exon 2 and exon 3. Cre-mediated recombination removed the selection cassette. (J:214484)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tnfrsf19 (mouse) Summary of all recombinase alleles driven by Tnfrsf19. Comparative matrix view of recombinase activities Alliance mouse Tnfrsf19 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf19 Mutation: 35 strains or lines available

References

• Original: J:214484 Stange DE, et al., Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epithelium. Cell. 2013 Oct 10;155(2):357-68
• All: 4 reference(s)