Gpnmb^tm1Ari
Targeted Allele Detail

Summary

• Symbol: Gpnmb^tm1Ari
• Name: glycoprotein (transmembrane) nmb; targeted mutation 1, Kiyoshi Ariizumi
• MGI ID: MGI:5608675
• Synonyms: DC-HIL^-
• Gene: Gpnmb Location: Chr6:49013449-49044413 bp, + strand Genetic Position: Chr6, 23.82 cM
• Alliance: Gpnmb^tm1Ari page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215931
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP flanked neo cassette replaced exons 2-4. RT-PCR confirmed absence of RNA in bone marrow-derived dendritic cells. (J:215931)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpnmb Mutation: 39 strains or lines available

References

• Original: J:215931 Chung JS, et al., DC-HIL-expressing myelomonocytic cells are critical promoters of melanoma growth. J Invest Dermatol. 2014 Nov;134(11):2784-94
• All: 2 reference(s)