Plcl1tm1.1Matk
Targeted Allele Detail
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Symbol: |
Plcl1tm1.1Matk |
Name: |
phospholipase C-like 1; targeted mutation 1.1, Matilda Katan |
MGI ID: |
MGI:5607951 |
Synonyms: |
Plce- |
Gene: |
Plcl1 Location: Chr1:55445080-55793444 bp, + strand Genetic Position: Chr1, 28.15 cM
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Alliance: |
Plcl1tm1.1Matk page
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Increase in TPA-induced skin proliferation in Plcl1tm1.1Matk/Plcl1tm1.1Matk and Plcl1tm2.1Matk/Plcl1tm2.1Matk mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:207384
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exon 2 was disrupted, a frameshift mutation was created in exon 3 and a floxed selection cassette was inserted via homologous recombination. Cre mediated recombination removed the neo cassette. Quantitative RT-PCR confirmed the absence of mRNA expression in homozygous mice.
(J:207384)
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Generation of the Plcl1tm1.1Matk allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Plcl1 Mutation: |
54 strains or lines available
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Original: |
J:207384 Martins M, et al., Tumor suppressor role of phospholipase C{varepsilon} in Ras-triggered cancers. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4239-44 |
All: |
1 reference(s) |
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