Rgs4^tm1Sdlk
Targeted Allele Detail

Summary

• Symbol: Rgs4^tm1Sdlk
• Name: regulator of G-protein signaling 4; targeted mutation 1, Andrew Siedlecki
• MGI ID: MGI:5605686
• Synonyms: rgs4^fl
• Gene: Rgs4 Location: Chr1:169569046-169575211 bp, - strand Genetic Position: Chr1, 76.84 cM
• Alliance: Rgs4^tm1Sdlk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:215588
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a single loxP site upstream of exon 2, and a loxP-flanked neomycin resistance (neo) cassette downstream of exon 5 of the gene. (J:215588)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs4 Mutation: 18 strains or lines available

References

• Original: J:215588 Pang P, et al., RGS4 inhibits angiotensin II signaling and macrophage localization during renal reperfusion injury independent of vasospasm. Kidney Int. 2015 Apr;87(4):771-83
• All: 1 reference(s)