Tg(Wnt1-rtTA2S*M2)1Whsu
Transgene Detail

Summary

• Symbol: Tg(Wnt1-rtTA2S*M2)1Whsu
• Name: transgene insertion 1, Wei Hsu
• MGI ID: MGI:5605471
• Synonyms: Wnt1-rtTA
• Transgene: Tg(Wnt1-rtTA2S*M2)1Whsu Location: unknown
• Alliance: Tg(Wnt1-rtTA2S*M2)1Whsu page

Transgene origin

• Strain of Origin: (C57BL/6J x CBA/J)F1

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: The transgenic construct contains an modified form of reverse tetracycline-controlled transactivator, under the control of the mouse Wnt1, wingless-type MMTV integration site family, member 1, promoter and enhancer. This version of rtTA contains 5 amino acid changes in the TetR moiety (S12G, E19G, A56P, D148E, and H179R) and a synthetic optimized transactivating domain. This rtTA has reduced basal activity and enhanced doxycycline sensitivity compared to wild-type rtTA. (J:155252)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:155252 Hsu W, et al., Manipulating gene activity in Wnt1-expressing precursors of neural epithelial and neural crest cells. Dev Dyn. 2009 Aug 3;239(1):338-345
• All: 2 reference(s)