Tg(TcraBO4H9.1,TcrbBO4H9.1)7Aog
Transgene Detail

Summary

• Symbol: Tg(TcraBO4H9.1,TcrbBO4H9.1)7Aog
• Name: transgene insertion 7 Anne O'Garra
• MGI ID: MGI:5603581
• Synonyms: TCR7
• Transgene: Tg(TcraBO4H9.1,TcrbBO4H9.1)7Aog Location: unknown
• Alliance: Tg(TcraBO4H9.1,TcrbBO4H9.1)7Aog page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(TcraBO4H9.1,TcrbBO4H9.1)7Aog expresses 2 genes
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tcra (MGI:98553)
  mouse	Tcrb (MGI:98578)

• Mutation details: DNA constructs carrying functionally rearranged anti-hen egg lysozyme (HEL) TCR Valpha11 andVbeta3 chain genes were obtained from a HEL-specific T cell hybridoma BO4H9.1 which recognizes a subdominant but not cryptic peptide of HEL and injected in fertilized eggs. This line is derived from one of the two founders created. (J:116743)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available

References

• Original: J:116743 Neighbors M, et al., Breakpoints in immunoregulation required for Th1 cells to induce diabetes. Eur J Immunol. 2006 Sep;36(9):2315-23
• All: 4 reference(s)