Skint1^m1Tac
Spontaneous Allele Detail

Summary

• Symbol: Skint1^m1Tac
• Name: selection and upkeep of intraepithelial T cells 1; mutation 1, Taconic
• MGI ID: MGI:5588374
• Synonyms: Skint1^FVB(Tac), Skint1 ^Glu324Stop
• Gene: Skint1 Location: Chr4:111863466-111886735 bp, + strand Genetic Position: Chr4, 51.53 cM
• Alliance: Skint1^m1Tac page

Mutation origin

• Strain of Origin: FVB/NTac

Mutation description

• Allele Type: Spontaneous
• Mutation: Nucleotide substitutions
• Mutation details: A spontaneous point mutation (GAA to TAA) results in the amino acid substitution of a stop codon for glutamate at position 324 (Q324X). This mutation is fixed in the FVB/NTac strain. (J:139711)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Skint1 Mutation: 35 strains or lines available

References

• Original: J:139711 Boyden LM, et al., Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Nat Genet. 2008 May;40(5):656-62
• All: 9 reference(s)