Ntrk1^tm2.1Tes
Targeted Allele Detail

Summary

• Symbol: Ntrk1^tm2.1Tes
• Name: neurotrophic tyrosine kinase, receptor, type 1; targeted mutation 2.1, Lino Tessarollo
• MGI ID: MGI:5588369
• Synonyms: TrkA^deltaKFG
• Gene: Ntrk1 Location: Chr3:87685551-87702469 bp, - strand Genetic Position: Chr3, 38.62 cM
• Alliance: Ntrk1^tm2.1Tes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209600
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: A floxed neo cassette was inserted in intron 11 and nine nucleotides encoding a KFG motif was removed from exon 11. The neo cassette was subsequently removed by cre-mediated recombination. Transcription was not affected but protein levels were elevated. (J:209600)

Expression

In Mice Carrying this Mutation:

3 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk1 Mutation: 60 strains or lines available

References

• Original: J:209600 Kiris E, et al., TrkA in vivo function is negatively regulated by ubiquitination. J Neurosci. 2014 Mar 12;34(11):4090-8
• All: 2 reference(s)