Hamp^tm2Svl
Targeted Allele Detail

Summary

• Symbol: Hamp^tm2Svl
• Name: hepcidin antimicrobial peptide; targeted mutation 2, Sophie Vaulont
• MGI ID: MGI:5582415
• Synonyms: Hamp^lox
• Gene: Hamp Location: Chr7:30641793-30643454 bp, - strand Genetic Position: Chr7, 19.27 cM
• Alliance: Hamp^tm2Svl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:211683
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 2 and 3 were flanked by lox-P sites, followed by a FRT-Hygro-FRT cassette in intron 3. FLP-mediated recombination removed the FRT-flanked Hygro sequence. (J:211683)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hamp Mutation: 17 strains or lines available

References

• Original: J:211683 Zumerle S, et al., Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype. Blood. 2014 Jun 5;123(23):3646-50
• All: 6 reference(s)