Tg(tetO-Fgf10)1Jaw
Transgene Detail

Summary

• Symbol: Tg(tetO-Fgf10)1Jaw
• Name: transgene insertion 1, Jeffrey A Whitsett
• MGI ID: MGI:5581842
• Synonyms: Tet-Fgf10, (teto)7CMV-FGF-10
• Transgene: Tg(tetO-Fgf10)1Jaw Location: unknown
• Alliance: Tg(tetO-Fgf10)1Jaw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO-Fgf10)1Jaw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Fgf10 (MGI:1099809)

• Mutation details: The transgenic insert is comprised of the mouse Fgf10 gene followed by the 3' UTR of the bovine growth hormone gene (polyA), under the control of (teto)₇CMV, which contains seven direct repeats of the tetracycline operator sequence fused to a bidirectional cytomegalovirus (CMV) minimal promoter. Founder lines A and B (described in the original reference) were also generated. (J:68525)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:68525 Clark JC, et al., FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am J Physiol Lung Cell Mol Physiol. 2001 Apr;280(4):L705-15
• All: 10 reference(s)