Hprt1^{tm1(tetO-Dkk1)Spdl}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1(tetO-Dkk1)Spdl}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1, Stijn De Langhe
• MGI ID: MGI:5581839
• Synonyms: Tet-Dkk1
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1(tetO-Dkk1)Spdl} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:178444
• Parent Cell Line: BPES (ES Cell)
• Strain of Origin: (129-Hprt1^b-m3 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Hprt1^{tm1(tetO-Dkk1)Spdl} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dkk1 (MGI:1329040)

• Mutation details: A targeting vector containing the tetracycline responsive promoter driving inducible expression of Dkk1 was inserted into the endogenous Hprt locus on the X chromosome. (J:101977, J:178444)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:178444 Volckaert T, et al., Parabronchial smooth muscle constitutes an airway epithelial stem cell niche in the mouse lung after injury. J Clin Invest. 2011 Nov 1;121(11):4409-19
• All: 5 reference(s)