Nsdhl^tm1.1Hrm
Targeted Allele Detail

Summary

• Symbol: Nsdhl^tm1.1Hrm
• Name: NAD(P) dependent steroid dehydrogenase-like; targeted mutation 1.1, Gail Herman
• MGI ID: MGI:5581334
• Synonyms: Nsdhl^flx5
• Gene: Nsdhl Location: ChrX:71962163-72002120 bp, + strand Genetic Position: ChrX, 37.29 cM
• Alliance: Nsdhl^tm1.1Hrm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:220990
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: An FRT flanked neo cassette and loxP site were inserted upstream of exon 5 and a loxP site was inserted downstream of exon 5 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:220990)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nsdhl Mutation: 8 strains or lines available

References

• Original: J:220990 Cunningham D, et al., Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development. Hum Mol Genet. 2015 May 15;24(10):2808-25
• All: 2 reference(s)