Tg(Tek-Nfkbia*S32A*S36A)1Gkl
Transgene Detail

Summary

• Symbol: Tg(Tek-Nfkbia*S32A*S36A)1Gkl
• Name: transgene insertion 1, George Kollias
• MGI ID: MGI:5575645
• Synonyms: Tg(Tie2-IkB)1Gkl, Tie2DNIkappaBalpha, Tie2floxedstop-IkappaBalpha
• Transgene: Tg(Tek-Nfkbia*S32A*S36A)1Gkl Location: unknown
• Alliance: Tg(Tek-Nfkbia*S32A*S36A)1Gkl page

Transgene origin

• Strain of Origin: C57BL/6 or CBA

Transgene description

• Transgene Type: Transgenic (Conditional ready, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The 19 kb transgene construct contains the Tek (endothelial-specific receptor tyrosine kinase; formerly Tie2) promoter followed by a loxP-flanked Stop signal, a beta-globin intron and a cDNA encoding a hemagglutinin- (HA-) tagged NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; also called IkappaBalpha) with alanine substituted for serine at amino acid positions 32 (S32A) and 36 (S36A). Upon cre recombinase expression, mice bearing this transgene express this superrepressor of NF-kappaB specifically in endothelial cells. (J:82809)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:82809 European Mouse Mutant Archive, Information obtained from the European Mouse Mutant Archive (EMMA). Unpublished. 2003-2013
• All: 1 reference(s)