Syvn1^tm1.1Dfan
Targeted Allele Detail

Summary

• Symbol: Syvn1^tm1.1Dfan
• Name: synovial apoptosis inhibitor 1, synoviolin; targeted mutation 1.1, Deyu Fang
• MGI ID: MGI:5575555
• Synonyms: Hrd1^f
• Gene: Syvn1 Location: Chr19:6096606-6103742 bp, + strand Genetic Position: Chr19, 4.34 cM, cytoband A
• Alliance: Syvn1^tm1.1Dfan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209597
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exons 8 to 11 were floxed and an FRT-flanked neomycin cassette was inserted via homologous recombination. FLP-mediated recombination removed the neomycin cassette. (J:209597, J:219656)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Syvn1 Mutation: 26 strains or lines available

References

• Original: J:209597 Wu T, et al., Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev. 2014 Apr 1;28(7):708-22
• All: 14 reference(s)