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Transgene Detail
Symbol: Tg(Ltf-icre)14Mmul
Name: transgene insertion 14, Mathias Muller
MGI ID: MGI:5571915
Synonyms: Ltf-Cre
Transgene: Tg(Ltf-icre)14Mmul  Location: unknown  
Alliance: Tg(Ltf-icre)14Mmul page
Strain of Origin:  (C57BL/6 x 129/Sv)F1
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Tg(Ltf-icre)14Mmul expression driven by 1 gene
Mutation detailsA BAC (RP24-166N8) containing the Ltf gene was modified in bacterial cells to produce the targeting construct. A cassette containing codon-improved cre recombinase (icre), an artificial intron, the bovine growth hormone polyadenylation signal and an frt-flanked ampicillin selection marker was inserted into the first exon of Ltf. A plasmid endoding Flp was transfected into E. coli cells to delete the amp-marker. The BAC construct was verified by sequencing and microinjected into pronuclei of (B6/129Sv)F1 oocytes to produce transgenic animals. 2 lines (14 and 15) were obtained. Line 14 was chosen for further analysis. (J:210800)
 Tissue activity of this recombinase allele
Driver: Ltf (species not specified)
Summary of all recombinase alleles driven by Ltf.

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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Original:  J:210800 Kovacic B, et al., Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells. Haematologica. 2014 Jun;99(6):1006-15
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory