Tg(Alb-HEL)3Ccg
Transgene Detail

Summary

• Symbol: Tg(Alb-HEL)3Ccg
• Name: transgene insertion 3, Christopher C Goodnow
• MGI ID: MGI:5571881
• Synonyms: AL3, Tg(Alb-LYZ)3Ccg, Tg(AlsHEL)3Ccg
• Transgene: Tg(Alb-HEL)3Ccg Location: unknown
• Alliance: Tg(Alb-HEL)3Ccg page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Alb-HEL)3Ccg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  chicken	LYZ (396218)	Murine Lyz gene is tandemly duplicated with 92% amino acid identity.

• Mutation details: This transgene comprises a genomic DNA fragment containing the coding region of the chicken lysozyme (also called hen egg lysozyme, HEL) gene joined to the 5' promoter elements of the liver-specific mouse abumin gene. The mean HEL concentration, measured by enzyme-linked immunosorbent assay (ELISA), in sera of mice of this line is 58 ng/ml; serum HEL levels in female mice are approximately twice those in males. (J:104190, J:127344, J:210801)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:210801 Goodnow CC, et al., Clonal silencing of self-reactive B lymphocytes in a transgenic mouse model. Cold Spring Harb Symp Quant Biol. 1989;54 Pt 2:907-20
• All: 3 reference(s)