Herpud1^tm1Kame
Targeted Allele Detail

Summary

• Symbol: Herpud1^tm1Kame
• Name: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; targeted mutation 1, Koichi Kokame
• MGI ID: MGI:5571583
• Gene: Herpud1 Location: Chr8:95113066-95122005 bp, + strand Genetic Position: Chr8, 46.46 cM, cytoband C5
• Alliance: Herpud1^tm1Kame page

Decreased cerebral infarction size in Herpud1^tm1Kame/Herpud1^tm1Kame mice following temporary three-vessel occlusion

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:210654
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

Allele Type: Targeted (Null/knockout, Reporter) Mutations: Insertion, Intragenic deletion Mutation details: An IRES, lacZ and neomycin resistance cassette replaced exons 2 through 8. Western blot analysis confirmed the absence of protein expression in the liver, pancreas and kidney. (J:210654)

Generation of the Herpud1^tm1Kame allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Herpud1 Mutation: 32 strains or lines available

References

• Original: J:210654 Eura Y, et al., Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice. PLoS One. 2012;7(3):e34298
• All: 3 reference(s)