Kmo^tm1Pjmi
Targeted Allele Detail

Summary

• Symbol: Kmo^tm1Pjmi
• Name: kynurenine 3-monooxygenase; targeted mutation 1, Paul J Muchowski
• MGI ID: MGI:5569394
• Synonyms: Kmo^{flox (ex5)}
• Gene: Kmo Location: Chr1:175459759-175488419 bp, + strand Genetic Position: Chr1, 81.6 cM
• Alliance: Kmo^tm1Pjmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207199
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Hypomorph) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 5. Authors state that this allele produces a product that is hypomorphic for kynurenine 3-monooxygenase activity. (J:207199)

Generation of the Kmo^tm1Pjmi allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmo Mutation: 36 strains or lines available

References

• Original: J:207199 Giorgini F, et al., Targeted deletion of kynurenine 3-monooxygenase in mice: a new tool for studying kynurenine pathway metabolism in periphery and brain. J Biol Chem. 2013 Dec 20;288(51):36554-66
• All: 1 reference(s)