Hprt1^{tm1.1(CAG-DLL1*,-Venus)Gos}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm1.1(CAG-DLL1*,-Venus)Gos}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 1.1, Achim Gossler
• MGI ID: MGI:5569238
• Synonyms: DL1ICD
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm1.1(CAG-DLL1*,-Venus)Gos} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209193
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Hprt1^{tm1.1(CAG-DLL1*,-Venus)Gos} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  DLL1 (28514)

  Dll1	(MGI:104659)

• Mutation details: The targeting construct introduced into the locus a CAG promoter, loxP site, neomycin resistance cassette, loxP2272 site, the intracellular domain encoding human cDNA, IRES, Venus gene, a polyadenylation sequence, loxP site and loxP2272 site. Cre-mediated recombination removed the selection cassette. (J:209193)

Generation of the Hprt1^{tm1.1(CAG-DLL1*,-Venus)Gos} allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1274 strains or lines available

References

• Original: J:209193 Redeker C, et al., Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo. PLoS One. 2013;8(10):e79050
• All: 1 reference(s)