Sh2b1^tm2.1Lr
Targeted Allele Detail

Summary

• Symbol: Sh2b1^tm2.1Lr
• Name: SH2B adaptor protein 1; targeted mutation 2.1, Liangyou Rui
• MGI ID: MGI:5568997
• Synonyms: SH2B1^flox
• Gene: Sh2b1 Location: Chr7:126066166-126074596 bp, - strand Genetic Position: Chr7, 69.06 cM
• Alliance: Sh2b1^tm2.1Lr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209019
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. (J:209019)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2b1 Mutation: 48 strains or lines available

References

• Original: J:209019 Chen Z, et al., SH2B1 in beta-cells regulates glucose metabolism by promoting beta-cell survival and islet expansion. Diabetes. 2014 Feb;63(2):585-95
• All: 4 reference(s)