Pip4k2a^tm1.1Lca
Targeted Allele Detail

Summary

• Symbol: Pip4k2a^tm1.1Lca
• Name: phosphatidylinositol-5-phosphate 4-kinase, type II, alpha; targeted mutation 1.1, Lewis C Cantley
• MGI ID: MGI:5568929
• Synonyms: PIP4K2A^flx
• Gene: Pip4k2a Location: Chr2:18847066-19002937 bp, - strand Genetic Position: Chr2, 12.93 cM
• Alliance: Pip4k2a^tm1.1Lca page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205288
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 2 was flanked by loxP sites. In addition, a neomycin resistance cassette flanked by Frt sites was inserted upstream of exon 2 and was removed via FLP-mediated recombination. (J:205288)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pip4k2a Mutation: 14 strains or lines available

References

• Original: J:205288 Emerling BM, et al., Depletion of a putatively druggable class of phosphatidylinositol kinases inhibits growth of p53-null tumors. Cell. 2013 Nov 7;155(4):844-57
• All: 3 reference(s)