Gad2^tm1(cre)Bvz
Targeted Allele Detail

Summary

• Symbol: Gad2^tm1(cre)Bvz
• Name: glutamic acid decarboxylase 2; targeted mutation 1, Boris V Zemelman
• MGI ID: MGI:5568691
• Synonyms: Gad65-cre
• Gene: Gad2 Location: Chr2:22512262-22583889 bp, + strand Genetic Position: Chr2, 15.15 cM, cytoband A-B
• Alliance: Gad2^tm1(cre)Bvz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209715
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6 x 129/Sv

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Gad2^tm1(cre)Bvz expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gad2 (MGI:95634)

• Mutation details: The cre recombinase coding sequence following an internal ribosome entry site (IRES-cre) was inserted into the 3' UTR of the Gad2 (Gad65) gene by homologous recombination in ES cells. (J:209715)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gad2 (mouse) Summary of all recombinase alleles driven by Gad2. Comparative matrix view of recombinase activities Alliance mouse Gad2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gad2 Mutation: 60 strains or lines available

Notes

ES cells = C57BL/6-129/SV hybrid cells.

References

• Original: J:209715 Lovett-Barron M, et al., Regulation of neuronal input transformations by tunable dendritic inhibition. Nat Neurosci. 2012 Mar;15(3):423-30, S1-3
• All: 1 reference(s)