Gt(ROSA)26Sor^{tm1(CAG-glc-1,-glc-2*,-EYFP)Jjan}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1(CAG-glc-1,-glc-2*,-EYFP)Jjan}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Joanna L Jankowsky
• MGI ID: MGI:5568108
• Synonyms: GluCl^YFP
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1(CAG-glc-1,-glc-2*,-EYFP)Jjan} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206513
• Parent Cell Line: JM8 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Mutation details: The targeting vector inserted into the locus a CAG prmoter, floxed 2.7 kb neomycin resistance/stop cassette, codon optimized C. elegans glutamate-gated chloride channel (alpha and beta genes separated by a TaV 2A sequence), a second TaV 2A sequence, EYFP gene and woodchuck hepatitis virus posttranscriptional regulatory element (WPRE). Cre-mediated recombination is required to achieve expression of the reporter. (J:206513)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1062 strains or lines available

References

• Original: J:206513 Sun MY, et al., Specificity and efficiency of reporter expression in adult neural progenitors vary substantially among nestin-CreER(T2) lines. J Comp Neurol. 2014 Apr 1;522(5):1191-208
• All: 1 reference(s)