Gabbr2^tm1.1Stmo
Targeted Allele Detail

Summary

• Symbol: Gabbr2^tm1.1Stmo
• Name: gamma-aminobutyric acid type B receptor subunit 2; targeted mutation 1.1, Stephen J Moss
• MGI ID: MGI:5568072
• Synonyms: S783A
• Gene: Gabbr2 Location: Chr4:46662318-46991714 bp, - strand Genetic Position: Chr4, 25.18 cM
• Alliance: Gabbr2^tm1.1Stmo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205570
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Constitutively active)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: A serine to alanine at amino acid 783 mutation was inserted into exon 16 and a floxed neo cassette was inserted in intron 16 via homologous recombination. Cre mediated recombination removed the neo cassette. The mutation in exon 16 eliminates a phosphorylation site. Absence of phosphorylation was confirmed by western blot analysis. Total GABBR2 protein expression was significantly increased in homozygous mice. (J:205570)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabbr2 Mutation: 61 strains or lines available

References

• Original: J:205570 Terunuma M, et al., Postsynaptic GABAB Receptor Activity Regulates Excitatory Neuronal Architecture and Spatial Memory. J Neurosci. 2014 Jan 15;34(3):804-16
• All: 2 reference(s)