Tg(ACTB-Tbx1,-GFP)1Bald
Transgene Detail
|
Symbol: |
Tg(ACTB-Tbx1,-GFP)1Bald |
Name: |
transgene insertion 1, Antonio Baldini |
MGI ID: |
MGI:5567088 |
Synonyms: |
COET, Conditional Over-Expression of Tbx1, FFCOET |
Transgene: |
Tg(ACTB-Tbx1,-GFP)1Bald Location: unknown
|
Alliance: |
Tg(ACTB-Tbx1,-GFP)1Bald page
|
|
Germline Transmission: |
Earliest citation of germline transmission:
J:146886
|
Parent Cell Line: |
E14TG2a.4 (ES Cell)
|
Strain of Origin: |
129P2/OlaHsd
|
|
Transgene Type: |
|
Transgenic (Inserted expressed sequence) |
Mutation: |
|
Insertion
|
|
|
Tg(ACTB-Tbx1,-GFP)1Bald expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Tbx1 (MGI:98493) |
|
|
|
|
Mutation details: The single-copy transgene comprises a chicken beta actin promoter followed by a loxP-flanked neomycin resistance cassette (neor) with a triple polyadenylation signal, a full-length cDNA encoding mouse T-box 1 protein (TBX1) with a Myc epitope tag, an internal ribosomal entry site (IRES) and a green fluorescent protein coding sequence. Upon cre recombinase-mediated recombination, neor is excised and the Tbx1 cDNA is expressed under control of the beta-actin promoter.
(J:146886)
|
|
|
Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
|
|
Original: |
J:146886 Vitelli F, et al., Gain of function of Tbx1 affects pharyngeal and heart development in the mouse. Genesis. 2009 Mar;47(3):188-95 |
All: |
3 reference(s) |
|