Mtch2^tm2.1Atgr
Targeted Allele Detail

Summary

• Symbol: Mtch2^tm2.1Atgr
• Name: mitochondrial carrier 2; targeted mutation 2.1, Atan Gross
• MGI ID: MGI:5566665
• Synonyms: Mtch2^delta
• Gene: Mtch2 Location: Chr2:90677499-90697154 bp, + strand Genetic Position: Chr2, 50.41 cM, cytoband E1
• Alliance: Mtch2^tm2.1Atgr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:209127
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: One loxP site was inserted just downstream of the 5' UTR and a second loxP site was located downstream of the FRT flanked PGK-neo cassette. The selection cassette was inserted just downstream of exon 3. Thus, exons 1-3 are flanked by loxP sites. Susequent germline deletion by cre expression deleted exons 1-3. (J:209127)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mtch2 Mutation: 24 strains or lines available

References

• Original: J:209127 Zaltsman Y, et al., MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat Cell Biol. 2010 Jun;12(6):553-62
• All: 1 reference(s)