Mir128-2^tm1.2Ans
Targeted Allele Detail

Summary

• Symbol: Mir128-2^tm1.2Ans
• Name: microRNA 128-2; targeted mutation 1.2, Anne Schaefer
• MGI ID: MGI:5563797
• Synonyms: miR-128-2^-
• Gene: Mir128-2 Location: Chr9:111947704-111947779 bp, - strand Genetic Position: Chr9, 62.46 cM
• Alliance: Mir128-2^tm1.2Ans page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205260
• Parent Cell Line: CY2.4 (ES Cell)
• Strain of Origin: B6(Cg)-Tyr^c-2J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of the microRNA region and an FRT flanked neo cassette and loxP site were inserted downstream of the region. Recombinase mediated recombination removed the neo cassette and the microRNA coding region. Expression of Mir128 was reduced by 80% in the brain of homozygous mice. (J:205260)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir128-2 Mutation: 0 strains or lines available

References

• Original: J:205260 Tan CL, et al., MicroRNA-128 governs neuronal excitability and motor behavior in mice. Science. 2013 Dec 6;342(6163):1254-8
• All: 1 reference(s)