Trim3^tm1.2Kstrn
Targeted Allele Detail

Summary

• Symbol: Trim3^tm1.2Kstrn
• Name: tripartite motif-containing 3; targeted mutation 1.2, Ronald van Kesteren
• MGI ID: MGI:5562431
• Synonyms: Trim3^l-, Trim3^tm1.2Mknl
• Gene: Trim3 Location: Chr7:105253670-105282778 bp, - strand Genetic Position: Chr7, 55.91 cM
• Alliance: Trim3^tm1.2Kstrn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:207738
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted upstream of exon 3. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 3 through 5. Western blot analysis confirmed the absence of protein expression in hippocampus, cerebellum and cortex. (J:207738)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trim3 Mutation: 37 strains or lines available

References

• Original: J:207738 Labonte D, et al., TRIM3 regulates the motility of the kinesin motor protein KIF21B. PLoS One. 2013;8(9):e75603
• All: 2 reference(s)