Rtel1^tm3.1Hdin
Targeted Allele Detail

Summary

• Symbol: Rtel1^tm3.1Hdin
• Name: regulator of telomere elongation helicase 1; targeted mutation 3.1, Hao Ding
• MGI ID: MGI:5559531
• Synonyms: RTEL1⁺v5
• Gene: Rtel1 Location: Chr2:180961532-180998409 bp, + strand Genetic Position: Chr2, 103.63 cM
• Alliance: Rtel1^tm3.1Hdin page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202812
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutation: Insertion
• Mutation details: A V5 epitope tag was added to exon 34. Cre-mediated recombination removed a floxed splice acceptor, IRES and beta-geo cassette inserted upstream of the modified exon 34. (J:202812)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtel1 Mutation: 75 strains or lines available

References

• Original: J:202812 Vannier JB, et al., RTEL1 is a replisome-associated helicase that promotes telomere and genome-wide replication. Science. 2013 Oct 11;342(6155):239-42
• All: 1 reference(s)