Slc30a8tm1.1Htwt
Targeted Allele Detail
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Symbol: |
Slc30a8tm1.1Htwt |
Name: |
solute carrier family 30 (zinc transporter), member 8; targeted mutation 1.1, Hirotaka Watada |
MGI ID: |
MGI:5558084 |
Synonyms: |
Slc30a8f |
Gene: |
Slc30a8 Location: Chr15:52158949-52199194 bp, + strand Genetic Position: Chr15, 19.88 cM
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Alliance: |
Slc30a8tm1.1Htwt page
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Low zinc content, insulin crystallization failure, and presence of atypical insulin granules in beta cells of Slc30a8tm1.1Htwt/Slc30a8tm1.1Htwt Tg(Ins2-cre)25Mgn/0 mice
Show the 1 phenotype image(s) involving this allele.
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Allele Type: |
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Targeted (Conditional ready, No functional change) |
Mutation: |
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Insertion
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Mutation details: An FRT-flanked neomycin resistance cassette with a 5' loxP site was inserted upstream of exon 5. An additional loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the selection cassette.
(J:204003)
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Generation of the Slc30a8tm1.1Htwt allele |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Slc30a8 Mutation: |
22 strains or lines available
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Original: |
J:204003 Tamaki M, et al., The diabetes-susceptible gene SLC30A8/ZnT8 regulates hepatic insulin clearance. J Clin Invest. 2013 Oct 1;123(10):4513-24 |
All: |
1 reference(s) |
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