Usp1^{tm1d(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Usp1^{tm1d(KOMP)Wtsi}
• Name: ubiquitin specific peptidase 1; targeted mutation 1d, Wellcome Trust Sanger Institute
• MGI ID: MGI:5556385
• Gene: Usp1 Location: Chr4:98812047-98823780 bp, + strand Genetic Position: Chr4, 45.6 cM
• Alliance: Usp1^{tm1d(KOMP)Wtsi} page
• IMPC: Usp1 gene page

Mutation origin

• Mutant Cell Line: EPD0039_1_E12
• Germline Transmission: Earliest citation of germline transmission: J:207363
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N
• Project Collection: KOMP-CSD

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion Vector: L1L2_gt2
• Mutation details: The L1L2_gt2 cassette was inserted at position 98816214 of Chromosome 4 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon 3 at position 98816874. The critical exon 3 is thus flanked by loxP sites. Flp- and cre-mediated recombination removed the reporter cassette and exon 3. (J:207363)

Expression

In Mice Carrying this Mutation:	14 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp1 Mutation: 47 strains or lines available

References

• Original: J:207363 Williams SA, et al., USP1 deubiquitinates ID proteins to preserve a mesenchymal stem cell program in osteosarcoma. Cell. 2011 Sep 16;146(6):918-30
• All: 1 reference(s)