Camk2dtm1.1Mean
Targeted Allele Detail
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Symbol: |
Camk2dtm1.1Mean |
Name: |
calcium/calmodulin-dependent protein kinase II, delta; targeted mutation 1.1, Mark Anderson |
MGI ID: |
MGI:5555902 |
Synonyms: |
CaMKIIdelta M281,282V, MM-VV |
Gene: |
Camk2d Location: Chr3:126389951-126639975 bp, + strand Genetic Position: Chr3, 55.97 cM
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Alliance: |
Camk2dtm1.1Mean page
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Germline Transmission: |
Earliest citation of germline transmission:
J:207291
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Parent Cell Line: |
W4 (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: Exon 11 was replaced with a modified exon 11 in which nucleotide substitutions result in the amino acid substitution of valine for methionine at positions 281 and 282. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of exon 12. The product of this allele is predicted to be oxidant-resistant.
(J:207291)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Camk2d Mutation: |
43 strains or lines available
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Original: |
J:207291 Luo M, et al., Diabetes increases mortality after myocardial infarction by oxidizing CaMKII. J Clin Invest. 2013 Mar 1;123(3):1262-74 |
All: |
7 reference(s) |
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