Gt(ROSA)26Sor^{tm3(bglA*)Dwi}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm3(bglA*)Dwi}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Douglas J Winton
• MGI ID: MGI:5555868
• Synonyms: R26^{[CA]30SYNbglA}
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm3(bglA*)Dwi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:202689
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: The targeting construct inserted into the locus an out-of frame and modified Caldocellum saccharolyticum gene that encodes a beta-glucosidase (SYNbglA) reporter gene with a CA30 dinucleotide repeat between the translational start site and remaining coding sequence. Replication slippage is required to achieve expression of the reporter. (J:202689)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

Notes

ES cell line = B6 1.1 (C57BL/6)

References

• Original: J:202689 Kozar S, et al., Continuous clonal labeling reveals small numbers of functional stem cells in intestinal crypts and adenomas. Cell Stem Cell. 2013 Nov 7;13(5):626-33
• All: 2 reference(s)