Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman
Transgene Detail

Summary

• Symbol: Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman
• Name: transgene insertion, Eva-Maria Mandelkow
• MGI ID: MGI:5554188
• Synonyms: antiaggregation, TauRD/deltaK280/I277P/I308P
• Transgene: Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman Location: unknown
• Alliance: Tg(tetO-MAPT*K280*I277P*I308P,-luc)#Eman page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The tetracycline response element with a bidirectional CMV promoter drives inducible expression of the four-repeat domain on human MAPT (TauRD; 244-372 aa) carrying the frontotemporal dementia and parkinsonism linked to chromosome 17 Lys280 deletion (deltaK280) and two proline mutations in the hexapeptide motifs, I277P and I308P, and a luciferase gene. The Lys280 deletion accelerates aggregation while the proline mutations inhibit MAPT (Tau) aggregation. (J:131379)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:131379 Mocanu MM, et al., The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy. J Neurosci. 2008 Jan 16;28(3):737-48
• All: 2 reference(s)