Lrrk2^tm3.1Mjfa
Targeted Allele Detail

Summary

• Symbol: Lrrk2^tm3.1Mjfa
• Name: leucine-rich repeat kinase 2; targeted mutation 3.1, Matthew Farrer
• MGI ID: MGI:5553130
• Gene: Lrrk2 Location: Chr15:91557378-91700323 bp, + strand Genetic Position: Chr15, 46.07 cM, cytoband F1
• Alliance: Lrrk2^tm3.1Mjfa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:101977
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector containing a FRT flanked PGK-NEO cassette and a loxP site was inserted downstream of exon 41. A second loxP site was inserted upstream of exon 41. Mutant mice were bred with Tg(ACTFLPe)9205Dym mice (on a C57BL/6 congenic background (N10)) to remove the neo selection cassette. (J:101977)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Lrrk2 Mutation: 156 strains or lines available

References

• Original: J:101977 The Jackson Laboratory, Information obtained from The Jackson Laboratory, Bar Harbor, ME. Unpublished. 2005-2017
• All: 2 reference(s)