Gt(ROSA)26Sor^{tm1.1(SORL1)Tew}
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{tm1.1(SORL1)Tew}
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Thomas E Willnow
• MGI ID: MGI:5553051
• Synonyms: Rosa26^TgSORLAwt, SORLA^wt
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{tm1.1(SORL1)Tew} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205418
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Gt(ROSA)26Sor^{tm1.1(SORL1)Tew} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  SORL1 (6653)

  Sorl1

  (MGI:1202296)

• Mutation details: The targeting construct inserted into the locus a wild-type human cDNA preceded by a splice acceptor and floxed neomycin resistance cassette and followed by a polyadenylation sequence. Cre-mediated recombination removed the resistance cassette and allowed for expression of the human cDNA. (J:205418)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 1089 strains or lines available

References

• Original: J:205418 Burgert T, et al., SORLA-dependent and -independent functions for PACS1 in control of amyloidogenic processes. Mol Cell Biol. 2013 Nov;33(21):4308-20
• All: 2 reference(s)