Mapk10^tm1Lewc
Targeted Allele Detail

Summary

• Symbol: Mapk10^tm1Lewc
• Name: mitogen-activated protein kinase 10; targeted mutation 1, Joseph W Lewcock
• MGI ID: MGI:5551898
• Gene: Mapk10 Location: Chr5:103056413-103359200 bp, - strand Genetic Position: Chr5, 49.61 cM, cytoband E4
• Alliance: Mapk10^tm1Lewc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201577
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: An FRT-flanked neomycin resistance cassette replaced most of exon 11. Western blot analysis confirmed the absence of protein expression in the retina. (J:201577)

Generation of the Mapk10^tm1Lewc allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk10 Mutation: 37 strains or lines available

References

• Original: J:201577 Huntwork-Rodriguez S, et al., JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. J Cell Biol. 2013 Sep 2;202(5):747-63
• All: 2 reference(s)