Rbm20^tm1Hgra
Targeted Allele Detail

Summary

• Symbol: Rbm20^tm1Hgra
• Name: RNA binding motif protein 20; targeted mutation 1, Henk Granzier
• MGI ID: MGI:5551818
• Synonyms: RBM20^deltaRRM
• Gene: Rbm20 Location: Chr19:53665737-53855511 bp, + strand Genetic Position: Chr19, 48.28 cM
• Alliance: Rbm20^tm1Hgra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:206713
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted
• Mutation: Intragenic deletion
• Mutation details: Exons 6 and 7, which encode the RNA recognition motif (RRM), were deleted. The neomycin resistance cassette remains intact. (J:206713)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rbm20 Mutation: 51 strains or lines available

References

• Original: J:206713 Buck D, et al., Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy. J Gen Physiol. 2014 Feb;143(2):215-30
• All: 10 reference(s)