Il6ratm1.2Jcbr
Targeted Allele Detail
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Symbol: |
Il6ratm1.2Jcbr |
Name: |
interleukin 6 receptor, alpha; targeted mutation 1.2, Jens C Bruning |
MGI ID: |
MGI:5550551 |
Gene: |
Il6ra Location: Chr3:89776631-89820503 bp, - strand Genetic Position: Chr3, 39.19 cM
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Alliance: |
Il6ratm1.2Jcbr page
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Germline Transmission: |
Earliest citation of germline transmission:
J:188445
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Parent Cell Line: |
Bruce 4 (ES Cell)
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Strain of Origin: |
B6.Cg-Thy1a
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: An FRT-flanked neo cassette with a 5' loxP site was inserted upstream of exon 2, and an additional loxP site was inserted downstream of exon 3. Flp-mediated recombination removed the selection cassette. Cre-mediated recombination removed exons 2 and 3. Western blot analysis confirmed the absence of protein expression in the liver, spleen, thymus and lymph node.
(J:188445)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Il6ra Mutation: |
35 strains or lines available
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Original: |
J:188445 Wunderlich CM, et al., Cutting edge: Inhibition of IL-6 trans-signaling protects from malaria-induced lethality in mice. J Immunol. 2012 May 1;188(9):4141-4 |
All: |
6 reference(s) |
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