Trp53^tm1Manf
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1Manf
• Name: transformation related protein 53; targeted mutation 1, James J Manfredi
• MGI ID: MGI:5550149
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1Manf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201153
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An FRT site and a loxP site were inserted in intron 10 and a neomycin resistance cassette followed by a second loxP site was inserted following exon 11. Finally, a second exon 11 with a stop codon in codon 367 (AAG to TAG change) was inserted after the second loxP site. (J:201153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 237 strains or lines available

References

• Original: J:201153 Hamard PJ, et al., The C terminus of p53 regulates gene expression by multiple mechanisms in a target- and tissue-specific manner in vivo. Genes Dev. 2013 Sep 1;27(17):1868-85
• All: 1 reference(s)