Nlk^tm1.1Ecan
Targeted Allele Detail

Summary

• Symbol: Nlk^tm1.1Ecan
• Name: nemo like kinase; targeted mutation 1.1, Ernesto Canalis
• MGI ID: MGI:5550140
• Synonyms: Nlk^loxP
• Gene: Nlk Location: Chr11:78457994-78588199 bp, - strand Genetic Position: Chr11, 46.74 cM
• Alliance: Nlk^tm1.1Ecan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:232075
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (129 x C57BL/6)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert a loxP site upstream of exon 2. A frt-flanked neomycin resistance (neo) cassette and a second loxP site was inserted downstream of exon 2. Mutant mice were bred with mice expressing Gt(ROSA)26Sor^tm1(FLP1)Dym to remove the neo selection cassette. (J:232075)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlk Mutation: 46 strains or lines available

Notes

ES cell line = "F1" (129 x C57BL/6).

References

• Original: J:232075 Canalis E, et al., Nemo-like kinase regulates postnatal skeletal homeostasis. J Cell Physiol. 2014 Nov;229(11):1736-43
• All: 6 reference(s)