Rorb^tm1.1Df
Targeted Allele Detail

Summary

• Symbol: Rorb^tm1.1Df
• Name: RAR-related orphan receptor beta; targeted mutation 1.1, Douglas Forrest
• MGI ID: MGI:5548298
• Synonyms: Rorb^1g, Rorb^GFP
• Gene: Rorb Location: Chr19:18907969-19088560 bp, - strand Genetic Position: Chr19, 13.28 cM
• Alliance: Rorb^tm1.1Df page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:205743
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Hypomorph, Modified isoform(s), Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A GFP replaced the coding sequence in the beta 1 first coding exon. The final allele lacks the self-excising neomycin resistance cassette inserted downstream of the GFP gene. Western blot analysis confirmed the absence of isoform beta 1 but expression of isoform beta 2. (J:205743)

Expression

In Mice Carrying this Mutation:	23 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rorb Mutation: 38 strains or lines available

References

• Original: J:205743 Liu H, et al., An isoform of retinoid-related orphan receptor beta directs differentiation of retinal amacrine and horizontal interneurons. Nat Commun. 2013;4:1813
• All: 9 reference(s)