Sqstm1^tm1.1Ewa
Targeted Allele Detail

Summary

• Symbol: Sqstm1^tm1.1Ewa
• Name: sequestosome 1; targeted mutation 1.1, Eiji Warabi
• MGI ID: MGI:5546006
• Synonyms: p62^flox
• Gene: Sqstm1 Location: Chr11:50090193-50101654 bp, - strand Genetic Position: Chr11, 30.36 cM, cytoband B1.2
• Alliance: Sqstm1^tm1.1Ewa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:201732
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 1 and a loxP site and FRT flanked selection cassette were inserted downstream of exon 1. The selection cassette was removed leaving exon 1 floxed. (J:201732)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sqstm1 Mutation: 32 strains or lines available

References

• Original: J:201732 Harada H, et al., Deficiency of p62/Sequestosome 1 causes hyperphagia due to leptin resistance in the brain. J Neurosci. 2013 Sep 11;33(37):14767-77
• All: 10 reference(s)