Tg(Foxp3-GFP)90Pkraj
Transgene Detail

Summary

• Symbol: Tg(Foxp3-GFP)90Pkraj
• Name: transgene insertion 90, Piotr Kraj
• MGI ID: MGI:5545653
• Synonyms: Foxp3^GFP
• Transgene: Tg(Foxp3-GFP)90Pkraj Location: unknown
• Alliance: Tg(Foxp3-GFP)90Pkraj page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Reporter)
• Mutation: Insertion
• Mutation details: The 186.8 kb C57BL/6 mouse bacterial artificial chromosome (BAC) RP23-446O15 containing the entire Foxp3 gene and other genes, was modified by inserting sequence encoding GFP (Green Fluorescent Protein) followed by a stop codon and the SV40 polyA signal, in frame with the start codon in exon 1 of the Foxp3 gene. None of the other loci on the BAC were modified. The construct is designed to prohibit expression of native or truncated Foxp3 protein. (J:152306)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:152306 Kuczma M, et al., Foxp3-deficient regulatory T cells do not revert into conventional effector CD4+ T cells but constitute a unique cell subset. J Immunol. 2009 Sep 15;183(6):3731-41
• All: 28 reference(s)