Jmjd1c^tm1Mtac
Targeted Allele Detail

Summary

• Symbol: Jmjd1c^tm1Mtac
• Name: jumonji domain containing 1C; targeted mutation 1, Makoto Tachibana
• MGI ID: MGI:5544070
• Gene: Jmjd1c Location: Chr10:66932189-67092105 bp, + strand Genetic Position: Chr10, 34.85 cM
• Alliance: Jmjd1c^tm1Mtac page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:203917
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The JmjC domain encoded by exons 24-27 was replaced with the IRES-neo cassette. RT-PCR analysis confirmed the absence of mRNA expression in the testes from homozygous mice.

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Jmjd1c Mutation: 222 strains or lines available

References

• Original: J:203917 Kuroki S, et al., JMJD1C, a JmjC domain-containing protein, is required for long-term maintenance of male germ cells in mice. Biol Reprod. 2013 Oct;89(4):93
• All: 2 reference(s)