Siglecftm1.1Avrk
Targeted Allele Detail
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Symbol: |
Siglecftm1.1Avrk |
Name: |
sialic acid binding Ig-like lectin F; targeted mutation 1.1, Ajit Varki |
MGI ID: |
MGI:5543405 |
Synonyms: |
siglecfflox |
Gene: |
Siglecf Location: Chr7:43000765-43008955 bp, + strand Genetic Position: Chr7, 28.25 cM, cytoband B3
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Alliance: |
Siglecftm1.1Avrk page
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Allele Type: |
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Targeted (Conditional ready, Hypomorph) |
Mutations: |
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Insertion, Single point mutation
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Mutation details: Exon 1 through 3 were floxed. Cre-mediated recombination removed a floxed neomycin resistance cassette inserted downstream of exon 3. A point mutation results in the amino acid substitution of alanine for arginine at position 114 (R114A). Western blot analysis confirmed an 80%-90% reduction in protein level of this severely hypomorphic allele.
(J:204811)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Siglecf Mutation: |
55 strains or lines available
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Original: |
J:204811 Zhang M, et al., Defining the in vivo function of Siglec-F, a CD33-related Siglec expressed on mouse eosinophils. Blood. 2007 May 15;109(10):4280-7 |
All: |
1 reference(s) |
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